Sunday, December 19, 2010

The good luck of the flaw that American medical research and China 2


Shoulder Dystocia Injury: 3D Medical Animation

Be what reason is caused does medicine of biologist dominant United States study this is planted today situation? In academy of American national sanitation (at the beginning of NIH) holds water, mix to make sure what medicine research is directional effectiveness, this academy made a provision: ?Institute Director) of  of  of gram of core of the greedy for food that confuse solder and each lab director (Laboratory/Branch Chief) must by double doctor‘s degree (M.d. adds biology to study a doctor) or M.d. degree gainer is held the position of, biologic research doctor can hold the position of task group leader only (Section Chief) or research scientist (Staff Scientist) . By did not break through down to society for a long time to study to medicine investment decreases at medical research wait for market economy element, a lot of outstanding double degree doctors and M.d. choice enter clinical medicine to the domain becomes a clinician and do not wish to consider to serve as his profession with medicine. Cause a large number of medicine to consider to get the shortage of military content so, the leadership position that below this kind of circumstance a lot of biology study to the doctor holds medicine to consider gradually, become the dean of school of college of medicine and research organization, strong point or director. This changes the medical research of type of farther aggravate take a part of the whole, make medicine research more deviated from oneself research target. Tell honestly, biologic research doctor is mixed in opposite content technology methodological control and perfectness respect exceed M.d. really, but we should realise clearly, biology technology is a tool of disease of conquer of human understanding disease merely, is not final research target. Replace a goal with the tool, can make with research of biologist dominant medicine medicine research only deviate orbit, make the end of human conquer disease more far. 4. Onefold medication disease---The place before the job that never finishs possibly is like is narrated, get machine reductive the impact that research research thinking, when American researcher is studying the hair interpretation of the cause of the disease manages focusing at the element of single live thing that concerns with the disease (albumen or gene) on unusual change, this member is being held after should discovering some biology element produces apparent change is the culprit that causes a disease, seek corresponding remedy consequently (depressor or intensifier) go defying this a member. The policy that means of this kind of thinking and research theory affect service of American medical treatment and management department of medicines and chemical reagents inevitably and code are made. For example American food and management board of medicines and chemical reagents (FDA) sets, the compound prescription that does not approve medicaments of two kinds of above enters clinical try out, can have single remedy only or most the clinical try out of medicine made of two or more ingredients of two kinds of pharmaceuticals. Reason is medicaments of two kinds of above is compound use the noxiousness side effect that adds medicaments likely. This also is Chinese traditional medicine the main reason that prescription cannot use in the United States. Here whether does the compound that we do not discuss medicaments of two kinds of above first add noxiousness side effect for certain, discuss single remedy to whether can treat a disease effectively first. Come for years, the manpower material resources with old pharmaceutical factory and each medical company much investment and financial capacity undertake the west the research and development of hundreds of kinds of new drug, but after these medicaments enter clinical try out, or discovery does not have curative effect to the patient, or produces the noxiousness side effect that makes a person anxious. Coverage of not long ago confirms, of research and development of American Pfizer company fight arthritic medicines- - COX-2 depressor kind anodyne (Vioxx, bextra and Celebrex) are prohibited continueing clinical try out, because of them not only indemonstrable have special curative effect to arthritis, can bring about the swift as the wind in heart disease and head to make instead, cause patient death even. Connect the ace product of Pfizer company research and development- - Wei elder brother (although Viagra) erects to male sex functional obstacle has curative effect, but because can cause heart disease,also be used by limitation. So far, outside dividing antibiotic to be able to control a bacterium effectively to contract sexual disease, still do not have a kind of specific to be able to treat a disease effectively. The crisis that the failure that what reason causes again and again of new drug research and development and pharmacy industry produce ceaselessly be? Germ is medicine of American type west research is existing blemish. Long-term since, western medicine research human body the definition is a machine, identifying humanness body occurrence disease to appear as the machine is You Mou like breakdown place of 10 components attaint is caused, the component that should find this damage only repairs it, the machine can work afresh again. Accordingly almost all medicine study the element of odd lifetime content that focusing causes a disease at searching, and medicationing also is around move the element of single live thing that how antagonism happening changes and spread out. Ground of one‘s own wishful thinking thinks, a kind of disease can use treatment of a kind of specific, not was necessary to also cannot use medicaments of two kinds of above to have compound treatment. Theory of this kind of research and practice are affecting what American medicine learns policy and code deeply to make undoubtedly. The fact proves, american FDA restricted the code that compound medicaments uses to violate the objective law that disease happening develops completely. Because the disease is a complex pathology change process, what it won‘t cause the change that also won‘t cause element of single live thing only by the change of element of single live thing only, the development process of the disease should be the biology inside the cell the unbalance process of molecular adjustment network. This adjusts network by by tens of thousands biology element (albumen or gene) be formed, the big big a wide place in the road that these biology elements live as us, join together each other through be similar to the biology signal of highway and railroad to deliver route, form the biology inside a complete cell molecular adjustment network. Below normal circumstance, the position that all biology element is maintaining relative stability (namely not heighten does not reduce) again, maintain the relative balance of whole network consequently, this kind of relative balance is human body cell and the main base that the organization develops normal physiology function. After disease happening, tens of even hundreds biology element produces corresponding change accordingly (some heighten, some reduces) , destroyed the relative balance of whole network system thereby, although the counteractive mechanism of human body oneself also tries to restore the balance of the network ceaselessly, the range that is like the network unbalance that the disease causes is too big, intensity is too strong, exceed the repair capacity of oneself, criterion network unbalance will develop toward not reversible direction, cause a cell finally death and organization are necrotic. And those who be aimed at element of single live thing medication can adjust only one of countless biology elements that change by disease place, although this kind adjusts very effective to element of corresponding single live thing, can change the active of this biology element and working position, also meet because of this part ground improves cellular biology the function of molecular adjustment network, but the normal balance that does not restore whole network effectively. This is great majority single remedy can alleviate only symptom and cannot effect a radical cure the likelihood of the disease reason. Terrible is, the active that changes element of single live thing and working status (break this biology molecule e.g. block) inevitable meeting is changed to it the working status of relevant other biology element and corresponding signal transfer access function, did not get resumptive evenly in cellular network, normal physiology function is put below the circumstance of the obstacle, can bring about the obstacle of other cell function instead, aggravate is whole the unbalance of cellular network, this is single remedy sometimes not only the likelihood that disables to be able to produce noxiousness side-effect and complication instead reason. Came 1988 through be opposite the single remedy curative effect with the apoplectic head of 95 kinds of cure that passes in the try out on animal model during 2004 undertakes evaluating, the average and significant percentage that the author discovers to these medicaments reduce a head to injure constituent capacity is only 37.8% , that is to say the area of cerebral tissue damage of 62.2% still exists, single remedy can not produce the remedial result of 40% only at most, basically be short of hematic loss to do not have too great help to treating a head. And group of a few research uses the United States head of cure of compound of two kinds of chemical remedy is injured (if NMDA suffers body Jie to fight agent Memantine and Clenbuterol of adrenal intensifier accepting put oneself in another‘s position compound use or Methylprednisolone and BDNF are compound use) , can make the head injures constituent capacity to reduce the 44.7% athletic functions that improved a head to injure Xiaobai rat apparently. The conditioning agent that the signal inside many cells uses to transfer network node gene when the author is considering to treat the new-style and compound medicaments that central nervous system injures (depressor or intensifier) make up compound medicaments cocktail. This kind of cocktail makes education cell is short of blood the surviving rate of 24 hours after anoxic injury is amounted to 80% , the bring down rate that organizes a capacity to damage of small rat brain also is achieved 72% . These experimental result specifications are onefold medication the disease has very big limitation, impossible from go up at all achieve the goal that cures a disease. If continue to count on,through research and development single remedy treats a disease, can be the job that never finishs possibly only. About the noxiousness side-effect problem of medicaments, we must understand medicaments to produce the postulate of noxiousness first. Any medicaments (no matter Western medicine still is Chinese traditional medicine) the use dose with should exceed regular only can produce noxiousness, form harm to human body. Even the vitamin with indispensible human body also is such, for example excessive takes vitamin E to cause heart disease possibly. The experiment research to discover, become two kinds or medicaments of two kinds of above is using effective treatment dose (namely the smallest dose of effect of therapy of single remedy generation) below the condition compound use its noxiousness can increase really. This also is American FDA thinks of medicaments of two kinds of above compound use the basis that increases noxiousness side effect likely. But, when wanting us to reduce the dosage of medicaments the 1/2 that treats dosage effectively or 1/4 only, of medicaments of two kinds of above compound use not only enhanced curative effect to reduce medicaments noxiousness instead. The compound remedy that the author uses method of conpatibility of medicines of this kind of medicaments to make up a variety of conditioning agent system of remedial central nervous to injure is cocktail, this kind of cocktail not only have obvious remedy effect and noxiousness side-effect greatly under the single remedy that uses effective treatment dose. The clinical practice of compound prescription also proves same Chinese traditional medicine, want to control medicaments dosage correctly only, a few kinds even of ten kinds of medicaments compound use and won‘t produce noxiousness side effect. The dose that because of Chinese traditional medicine of medicine made of two or more ingredients the dosage when conpatibility of medicines often uses alone under unit drug, before doing not have conpatibility of medicines, the unit drug of such dosage is effect of short of therapy. The effectiveness of pharmaceuticals medicine made of two or more ingredients is combining the function after forming whole each other at them. And a few accepted for poisonous medicaments, the use that should control them scientificly often can produce the magical curative effect that expect is less than after dosage, the Hong Kong that suffers cerebral scar because of traffic accident in England for example is defended inspect compere bang to be like a lady, announce her when British hospital already after cerebral death is cureless, it is Chinese traditional medicine makes her bring the dying back to life, and the ace Chinese traditional medicine that delivers her is An Gongniu yellow pill. This kind of An Gongniu contains Zhu Sha in Huang Wan (namely mercuric) , its have apparent noxiousness to human body. If press the standard of American FDA,this kind of medicine cannot be entered for certain clinical, but the clinical practice that is in China has proved An Gongniu yellow pill not only have distinct curative effect, what also do not have a lot of United States research and development is individual new drug is in that way serious noxiousness and side-effect. Additional, be located in Shanghai Zhang Jiang the China of high-tech garden area uses arsenic one kind when protection and development academy not long ago just developed Chinese traditional medicine of classical traditional Chinese medical science (3 oxidation 2 arsenic) the new treatment that treats AIDS, also produce the peculiar curative effect that expect is less than, and its poison side-effect can be controlled arrive the smallest. Arsenic is accepted bane, large dose is taken cause death necessarily. But control its correctly to make dosage can treat a disease however, benefit at the mankind, this consolidates the rule with respect to the differentiate card that is a thing. Because of FDA of this United States about medicaments of two kinds of above compound using what add medicaments noxiousness side effect likely to conclude is very one-sided with the objective law that violates science. 5. Medical revolution---The turning point with powerful the Chinese nation is close hundred years come, the change quickly of science and technology makes human society produced profound change, world each country realises new and high science and technology is to make the mankind progresses, economy grows, the real motive force with powerful nation. Who mastered advanced science and technology, who mastered future, mastered the world. The western medicine that by Wu Yimei the country is a delegate research to existing blemish, make the mankind is in completely passive position in the fight of conquer disease, wasted financial capacity of a lot of manpower material resources and valuable time, be these mistakes and blemish however the powerful nation of biology medicine science and technology that becomes future for China offerred precious opportunity. We should admit, make in machinery, the computer reachs IT, medicine diagnoses a technology, the respect such as development of medical apparatus and instruments, the United States and country of a few wests are already banner at China, but in medicine research and disease treat a field, china and United States still are in same scratch line to go up, and the United States still is carrying " machinery on the back reductive by " this heavy burden, beetle is worn " of " take a part of the whole this crutch. If can first start of a race, lead revolution of a medicine, china will become world medicine powerful nation completely likely. Once wait for the United States to realize his error, put down package and crutch banner start of a race, china should chase American general to must pay the price of special hardships again. Experience for years in the United States according to the author, the United States is the country with very strong capability of an ego error correction, its error correction ability comes from the adjustment of market economy, after the error that realizes oneself research a field in medicine, the action that it can carry economic lever very quickly (if change investment, study fund, product production and the way of going from place to place that the market throws) correct an error, make science research to develop toward right way. Notable is, academy of American national sanitation (the policy of biology medicine research of its director United States and research foundation) already studied at medicine of a biology was being started by 2003 route chart plans (NIH Roadmap) . The core of this plan is: Ji core of а of  Mo cellar chops? of  Gong arm front is clinical. Use new biology medicine technology to study the whole of the disease changes, encourage new research thinking, encourage technical innovation, expedite the research and development of new drug and clinical application. The issue that this shows to the United States also realizes him to exist in biology medicine research, begin to change its biology medicine to study policy. But the United States should drop a load completely, desertion crutch still still needs time a few years, this research in medicine for China the domain precedes start of a race offerred opportunity. To hold this once in a blue moon historical good luck, the medicine that the author suggests to just face China in the following research to undertake enrich and be adjustmented: 1) . The talent is fostered
Train double doctor energetically (M.d. adds biology to study a doctor) talent, the medical knowledge that makes they master comprehensive system namely masters sophisticated biology technology again, attract them to enter medicine to research a field with market economy shift at the same time, go direction of dominant medicine research, lead medicine to study a team. Of reasonable control M.d. and biologic research doctor yield, study in medicine the condition that did not obtain a breakthrough falls, clinical cure also won‘t have apparent progress. Because the education of this M.d. is main,the complement of clinical public health worker mixes with a view to change, make sure job of cure of daily medical treatment is begun effectively. Study to biology the doctor undertakes billabong, in the research team that attracts the biologist that research to concern with the disease double doctor medicine to study the expert is led, produce their biologic special skill and effect adequately, but cannot let a biologist go in that way like the United States dominant medicine research. Cannot produce the biologist‘s effect namely otherwise, block up medical development. The biologist that pure to be engaged in biology research, should encourage them to enter special biology technology institute, the biology department of company of biology science and technology or university goes be engaged in concentrated biology technology studying development and education work. Developing him person with ability while, create all conditions to attract of all kinds study abroad personnel goes back to the motherland service, pay attention to particularly attract double doctor‘s degree is obtained in abroad (M.d. adds biology to study a doctor) talent, or the talent that acquires medical degree to obtain biology to study a doctor in abroad again in China goes back to the motherland, the nuclear mental efforts in letting them make research team is measured and get military thing. 2) . Study way
The way that medicine research must face towards sickness make a diagnosis and give treatment, front is clinical. All research should closely around move the integral sex that explores a disease and spread out, the hair interpretation of the cause that is a disease mainly manages, diagnose and treat. The dispersive sex that prevents type of American take a part of the whole research with free selection of subject. In initial stage, we can choose disease of a few acute (like scar, chemical and toxic, the urgent sexy disease that catch a gender) undertake tackling key problem, the mutual connection of element of the biology in studying acute disease produces development process systematically in the round and colony change and whole cell adjust the change of the network. Choose acute disease to undertake tackling key problem first, because the animal model of acute disease duplicates more easily,be, come on time is shorter observe easily. The biology element that causes in ascertain acute disease and cell adjust after network whole changes, we can master the basic rule that disease happening develops and pathology foundation, it is chronic illness thereby (if heart disease, cancer, head is apoplectic,wait) research lays important foundation. Although the pathogeny because of urgent chronic illness is different, but the disease change process on the human body reaction to the disease and cell and molecular level should have certain intercommunity and similar sex. On specific research technique we can take the technical approach of " of " integrated medicine, comprehensive systematically collect is concentrated the information of the biology element of the disease and its signal access, build the database of information of medicine of computer live thing of this disease, of all biology member that with the computer analytic collect reachs and its signal access hand in collect connection, find out the join node in their join network and network, develop experimental treatment as drone with these join node then. On technical approach, applicable biology chip (gene and albumen chip) the member of big range biology with technology and new other determines the gene group that the technique goes studying the disease is caused, the integral change that albumen group and signal pass access and element of the biology inside the cell after the experiment is treated adjust the reaction of the network. 3) . Medicaments research and development
In respect of medicaments research and development, should be encouraged and promote the live thing inside cell of can effective balance the compound medicaments recipe of molecular adjustment network and Chinese traditional medicine the development of prescription. Medical practice has proved, single remedy treats a disease effectively, use adjust what network of element of the biology inside the cell balances is compound medication the method just may be the accurate method that cures a disease. Examine the standard with new drug whether successful research and development is: ? of arm of duckweed of acute communicable diseases of Yi travel е does not have apparent noxiousness side-effect to human body, is not the assorted amount of medicaments. The medicaments government laws and regulations that making China respect cannot overall copies the United States and western country all regulations systems and legal laws and regulations. American is not an immortal, they also are being explored ceaselessly, innovate ceaselessly, ceaseless generation is wrong, correct oneself error ceaselessly again. We object extremely arrogant, firm condition is self-given, but also cannot worship foreign things, overall is westernized. Cannot think all American things are the most advanced and best show, cannot think to conform with the world even if imitate the United States and western country more all law system, thinking means, organize structure and scientific research method. Human society is in ceaseless progress, science also is developing ceaselessly. Although China has the place that is inferior to the United States, but the place that also has excel United States, for example the most reasonable cure principle on the world of the doctor of traditional Chinese medicine before treating a principle to look namely. Although theory of doctor of traditional Chinese medicine is put in the flaw with serious move, cannot explain a lot of physiology pathology inside human body change scientificly, but by Wu Zhong cure theory is built at thousands of years before, science and technology is underdeveloped at that time, a lot of clinical phenomena can be used only a few have mysterious colorific doctrine to try to describe, create a traditional Chinese medical science to the person unscientific not rigorous impression. However remedial method of the doctor of traditional Chinese medicine and the practice that the principle passes a few chiliad examine to already proved to have its rationality, because it accords with the essence of the disease and objective law basically. Any thinking always the viewpoint that Chinese thing is inferior to the United States necessarily, it is the clammy expression that loses self-confident heart to oneself. 4) . Study policy
Medical is the science of a ceaseless development, examine medical research is correct, whether significant exclusive level is to see it whether announce correctly the mechanism of the disease, whether the remedial step with significant progress, whether the health that improves the mankind truly. is not to look publish how many paper, have how many honor, there is how many flowery aureola on the body. The field researchs in the science that explores sealed world, only seasoned person the cent of the person that lack with experience, without alleged an academic authority. The field researchs in medicine, american is not, also do not have the adviser that the qualification is a Chinese, can calculate the loser that has experience only at most. When accordingly the government sector is making medicine study policy, the lesson of should referenced United States and the experience with western successful country and failure, but cannot the thing that overall copies abroad (because biology medicine of the United States research policy and code also are in,change) ceaselessly, want to make the regulations system that suits medicine to study healthy progress, legal laws and regulations, organize structure and academic system, creation gets used to new relations of production to it. Should make full use of for example the constituent capability with Chinese very strong government, the main disease with healthy to minatory mankind tissue (heart disease, cancer, the head is apoplectic, AIDS, scar and all sorts of epidemic contagion) undertake those who have specific aim tackle key problem, the key gives to give aid to in research and development funds respect. Set relevant research task group for standard reset with the disease, by have double doctor (M.d. adds biology to study a doctor) the scientist of degree is gotten army, configure a certain quantity of clinician, biologist, chemist, mathematician, physicist and computer expert. Study resource and scientific research funds to avoid to seldom count person forestall, produce alleged an academic authority, in the light of the task of same disease research group should have many, make them mutual compete, preferred clean out bad. Study in same task the tenure of office that academic leader should fulfil in the group is made, it is a lieutenancy 5 years, if progress is obtained to be able to be connected on research,hold the post of, but if make progress to change through making public invite applications for a job without research,cannot exceed two; at most academic leader. This kind of lieutenancy makes the progress that will prevent because of limitation of level of academic leader knowledge or intellectual ageing block up science, make whole research team maintains active creativity from beginning to end, also prevent to consider scientificly to become a few people to fend at the same time the tool with pan. Studying train of thought, academic theory and technical measure respect, should not deviate from only total research target and direction should encourage innovation, encourage competition, encourage free development. If say Europe is the center of Industrial Revolution, the United States is the center of information revolution, china should have determination to become the center of medical revolution. This medicine revolution will get effecting a radical cure completely is a mark with the common disease of health of a few minatory mankinds. The Chinese nation is one clever with the nation that has creativity, want us to grasp an opportunity only, break a tradition, be brave in to go all out in work, regular meeting becomes powerful nation of world biology medicine.

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