Tuesday, December 7, 2010

The application that pig embryo does a cell to study in biology medical and look into


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Mammalian embryonic dry cell (Embryonicstemcells) department is born from bursa the cell is round in embryo (Innercellmass) , at ego second birth and infinite and proliferous cell character are being had outside body, and it is under appropriate adjusting control mechanism, provide development to become the place in 3 primitive germinal layer to have the potential of configuration cell. The relevant research of dry cell is open of embryonic development biology a new research field, and because embryo does a cell to have differentiation much can quality (the potential of Pluripotency) , therapeutics is replaced in prospective cell (Cellreplacementtherapy) , or is the application such as cellular transplanting and biology medical project, provided a source that has value. The research of dry cell already had a lot of outstanding positive result, include to revulsive mankind embryo does cellular become divided to form nerve to not have, cell of pancreas islet β and cardiac muscle cell, these achievement are in clinical get on OK at Pajinsen disease applying

Disease of food make water and heart disease the development of the new treatment that wait. In addition, in respect of nerve cell damage, the cell of dry cell replaces therapeutics to be able to derive nerve cell businesslikely a group of things with common features group, this is operated in prospective vertebrate have latent capacity quite on iatrical application.


A lot of research point out in human embryo dry cell and small rat embryo work a lot of otherness exist between the cell, because this thinks to place of experiment of rat embryo dry cell gets a result and can not apply at human embryo directly as a child,do a cell go up, the gene expression that concerns with nerve become divided especially and adjusting control mechanism; And common livestock product animal - pig, because be in,anatomy, immunity and physiological a lot of character are close to quite with the mankind, a lot of organ size that increase a pig also connect with the mankind close, reason this, the pig becomes the admirable animal pattern that provides research of medicine of human live pig. The pig once was done the animal mode that goes up for human sickness treatment, include to transplanting of congenital heart disease, hypertensive, organ and pharmacodynamics and toxicological experiment wait, and the character between dry cell of pig embryo dry cell and human embryo also is close to quite, both all need support to make offerings to the cell is fostered in all, and do not suffer leukaemia to control gene (Leukemia Inbibitoryfactor, LIF) restrains potential of its become divided. With respect to morphology and cytology particularity character, pig embryo dry cell and human embryo do a cell to be able to form dry cell community likewise (the dry cell of ES Cell Colony) is peculiar configuration, and both all can behave Stage-specificembryonicantigen3/4(SSEA3/4) , and all do not behave the SSEA1 antigen that sees at small rat embryo does a cell only.


Although be built from livestock product animal,have differentiation much can sexual embryo does a cell relatively rat kind difficult, like that the bursa embryo before this place physiology group writes a bed smoothly already oneself builds individual plant of as dry as embryo of develop live pig cell successfully, and after the course is proper and revulsive, but directional become divided becomes nerve cell, form kind of nerve network. Accordingly, future will lend the research that does a cell by pig embryo mode further, get human embryo does the important information that the place on cellular research obtains not easily then, hope to be able to be applied at nerve injury and degenerative remedial mode study.

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